Stents are the most common cardiovascular implants used in the treatment of cardiovascular diseases. However, there are concerns about in-stent renarrowing (restenosis) with bare metal stents and late stent thrombosis and inflammatory responses with drug-eluting stents. The endothelium is the lining of the blood vessels that is a thin layer of endothelial cells and underlying nanofibrillar basement membrane. It modulates vascular tone by release of factors such as nitric oxide. With stent deployment, there is inevitable injury to the endothelium, triggering a cascade of restenosis and thrombosis.
The Endomimetics bionanomatrix coating provides a prohealing environment, enhancing healing of the endothelial lining, inhibiting blood clot formation, and limiting restenosis. The coating is undergoing preclinical evaluation for coronary stents at the University of Alabama at Birmingham.