Secure patients' health with Endomimetics™

Our Backbone

Endomimetics™ strives to revolutionize procedural and implantable device outcomes by leveraging cutting-edge peptide-based nanotechnologies, such as its proprietary Bionanomatrix™, to promote healing, enhance device longevity, and improve patient care across medical applications.

Who we are

We are a team of scientists, innovators, and business leaders with a shared goal of changing the face of healing. Our Bionanomatrix™ technology and innovations were spun out of the University of Alabama at Birmingham, paving the way to the success of Endomimetics™.

Our Values

INNOVATION

Pursuing groundbreaking advancements in nanotechnology to improve patient outcomes and medical device performance.

Patient-centric solutions

Prioritizing safety, healing, and long-term health benefits in every product.

Scientific excellence

Upholding rigorous research and development standards to create reliable, evidence-based technologies.

Collaboration

Fostering partnerships with researchers, clinicians, and industry leaders to drive transformative solutions.

Integrity

Maintaining transparency, ethical practices, and a commitment to improving global healthcare.

OUR COMMITMENT

We are committed to transforming the lives of patients who undergo procedures by sending them home faster, safer, and better.

How We Operate

At Endomimetics™, we focus on developing innovative peptide-based coatings and gels like Bionanomatrix™ to enhance the safety and longevity of implantable medical devices. Our operations emphasize precision-driven research, leveraging multidisciplinary expertise in biomedical engineering and materials science. Through clinical collaboration and feedback, we tailor solutions to address unmet medical needs. We ensure our products meet stringent quality standards while actively pursuing regulatory approvals. Transparency, ethical conduct, and a commitment to advancing healthcare are the cornerstones of our daily operations.

OUR STORY

Endomimetics™ has its origins in the collaboration between two bioengineering visionaries: Brigitta Brott, M.D., an interventional cardiologist at UAB and Ho-Wook Jun, Ph.D., UAB Biomedical Engineering faculty. They developed a novel bionanomatrix coating to inhibit blood clot formation and renarrowing of arteries while enhancing the healing process for patients with coronary stents.

In an effort to bring the product to market, the pair applied for and received a Wallace Coulter Foundation grant, which matches biomedical faculty with a clinician/researcher. After attending the Coulter Foundation’s business training and an “Idea to IPO” class in the UAB School of Business, Brott and Jun determined the fastest way to get the coating to market was to form a company and partner with device manufacturers. Endomimetics was subsequently founded in November 2009 and now resides at Station 41.

  • 2009
  • 2014
  • 2015
  • 2016
  • 2017
  • 2019
  • 2021
  • 2022
  • 2023
  • 2024
2009

Endomimetics™ founded

Patent filed 8,735,354 “The Next Generation of Stent Coatings”

2014

Patent granted

2015

Funding award SBIR Phase 1

Bionanomatrix coating for brain aneurysm coils to enhance healing

Amount: $553,378.00
2016

Funding award SBIR Phase 1

Nitric oxide releasing nanomatrix wrap to enhance dialysis fistula maturation

Amount: $429,486.00
2017

Funding award SBIR Phase 1

Coating to enhance endothelialization after left atrial appendage closure

Amount: $463,188.00

Funding award SBIR Phase 2

Nitric oxide releasing nanomatrix to enhance dialysis fistula maturation. Successful grant completion in 2018

Amount: $1,913,191.00
2019

Funding award SBIR Phase 1

Enhanced endothelialization of nanomatrix coated flow diverter for intracranial aneurysms

Amount: $563,196.00
2021

Funding award SBIR Phase 2B

Nitric oxide releasing bionanomatrix to enhance dialysis fistula maturation

Amount: $1,918,521.00
2022

Funding award SBIR Phase 1

Dual-action drug coated balloon to mitigate neointimal hyperplasia and promote endothelialization

Amount: $497,306.00
2023

Partnership with BISCO, Inc

Endomimetics™ announces a research collaboration agreement with BISCO, Inc., to support the development of a dental application of Bionanomatrix™

Funding award SBIR Phase 1

Bionanomatrix coating to enhance antibacterial effects while reducing inflammation of knee joint implants

Amount: $292,643.00
2024

Funding award Innovate Alabama

Support the development and evaluate the potential of Bionanomatrix™ to reduce infectious and inflammatory complications of knee arthroplasty

Amount: $100,000

Funding award SBIR Phase 2

Enhanced endothelialization of nanomatrix coated flow diverter for intracranial aneurysms

Amount: $920,119

Funding award SBIR Phase 1

Atherosclerosis assay development for drug efficacy and cytotoxicity screening

Amount: $304,119

Join us on this journey

We are developing medical breakthroughs with our proprietary Bionanomatrix™ technology and invite you to join our transformative efforts. Your partnership can accelerate these exciting developments, helping us push the boundaries of medical technology and improve healthcare for everyone.

Dialysis and Vascular Access

With the award of multiple grants, we are applying our Bionanomatrix™ AVF Gel Formulation to treat arteriovenous fistulas (AVFs), enhancing the success rates of vascular access and improving patient outcomes. It is our goal to commercialize our gel and bring this therapy to market.

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Revolutionize Atherosclerosis Treatment

We have been entrusted with a NIH Small Business Innovation Research grant to refine a groundbreaking 3D in-vitro vascular model. This model mimics the human arterial layers affected by atherosclerosis, enhancing drug testing capabilities. It is our goal to automate this process, paving the way for quicker, safer drug development.

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Enhance Brain Aneurysm Interventions

With a $2.8 million NIH SBIR grant, our focus is on improving devices used to treat brain aneurysms. By incorporating Bionanomatrix™ onto flow diverters, we aim to reduce healing time and minimize complications, reducing the risks of bleeding and blood clot formation for patients with brain aneurysms. It is our goal to take a safer brain aneurysm therapy to market.

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Improve Knee Replacement Outcomes

Our initiative to reduce complications in knee replacement surgeries has been backed by NIH SBIR funding. By integrating the Bionanomatrix™ with knee implants, we are working towards preventing infections and reducing scarring. It is our goal to take these enhanced implants from the lab to the real world, significantly improving patient recovery.

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Advance Dental Restoration

In collaboration with BISCO, Inc., and funded by a grant, we are developing a new bioactive material for dental treatments. This innovative material aims to replace current direct pulp capping methods, offering more reliable and enduring outcomes. It is our goal to redefine dental care and provide lasting solutions.

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