Applications

Stents

Designed for use in vascular grafts and stents, Bionanomatrix™ technology helps reduce the risk of thrombosis and promotes healing. This significantly improves the outcomes of heart and vascular surgeries.

Key Features
  • Large Nitric Oxide (NO) Supply: A reservoir for sustained release of NO promotes healthy vasodilation and inhibits inflammation.
  • Endothelial Cell Adhesive Molecule: An endothelial cell adhesive molecule, which promotes retention of endothelial cells.
  • Self-Assembling Amino Acids: Self-assembling amino acid chains that are free of solvents typically used in device coatings, which may cause inflammation or be toxic.
Benefits
  • Inhibits blood clot formation.
  • Inhibits re-narrowing within a stent or implant.
  • Encourages healing of the normal arterial lining.
  • Lacks residual polymer or solvent.
  • Comprised of completely natural, peptide-based nanofibers.

Dialysis and Vascular Access

The Bionanomatrix™ Arteriovenous Fistula (AVF) Gel Formulation is designed to greatly improve the maturation of the preferred vascular access for dialysis – AVFs, which have a 60% failure rate. It achieves this by improving vasodilation, enhancing healthy healing, and limiting neointimal hyperplasia. 

This NO-releasing gel technology is a peptide amphiphile (PA)-based formulation. It consists of a nanomatrix of self-assembling peptides with a dual functionality: one part binds endothelial cells to encourage healing, while the other releases NO in a controlled, sustained manner. The gel has potential applications in other vascular therapies as well.

Key Features
  • Endothelial-Mimicking Structure: Mimics the natural endothelium to reduce inflammation and abnormal cell growth.
  • Controlled NO Release: Releases NO gradually over weeks, enhancing blood vessel dilation, minimizing clotting, and supporting cellular repair.
  • Tunable Composition: Customizable peptide ratios allow for controlled cell interaction and NO release, creating a stable gel for extended use without additional support.
Benefits
  • Minimizes inflammatory reactions.
  • Promotes vascular remodeling.
  • Supports healthy AVF maturation.

Literature

Below is a list of the technical literature on the various applications for the BioNanomatrix (click on the reference to download the PDF)

  • Maheshika Somarathna*, Patrick TJ. Hwang*, Reid C. Millican, Grant C. Alexander, Tatyana Isayeva-Waldrop, Jennifer A. Sherwood, Brigitta C. Brott, Isabella Falzon, Hannah Northrup, Yan-Ting Shiu, Chris J. Stubben, John Totenhagen, Ho-wook Jun, and Timmy Lee. Nitric oxide releasing nanomatrix gel treatment inhibits venous intimal hyperplasia and improves vascular remodeling in a rodent arteriovenous fistula. Biomaterials. 2022; 280, 121254.
  • Guang Ren, Patrick TJ. Hwang, Reid Millican, Juhee Shin, Brigitta C. Brott, Thomas Groen, Craig M. Powell, Sushant Bhatnager, Martin E. Young, Ho-Wook Jun, and Jeong-A Kim. Subcutaneous administration of a nitric oxide-releasing nanomatrix gel ameliorates obesity and insulin resistance in high-fat-diet-induced obese mice. ACS Applied Materials and Interfaces. 2022; 14(17), 19104-19115.
  • Patrick TJ. Hwang*, Jennifer A. Sherwood, Reid C. Milican, Pratheek S. Bobba, Tyler O. Lynd, Joseph N. Garner, Brigitta C. Brott, Dongming Hou, and Ho-Wook Jun. Endothelium-Mimicking Nanomatrix Coating to Enhance Endothelialization after Left Atrial Appendage Closure Device Implantation. ACS Applied Biomaterials. 2021; 4(6), 2917-4924
  • Grant C. Alexander, Patrick TJ. Hwang, Jun Chen, Jeong-a Kim, Brigitta C. Brott, Young Sup Yoon, Ho-Wook Jun. Nanomatrix coated stent enhances endothelialization but reduces platelet, smooth muscle cell, and monocyte adhesion under physiologic conditions. ACS Biomaterials Science & Engineering. 2018; 4(1), 107-115.
  • Jun Chen, Lily Deng, Catherine Porter, Grant Alexander, Dhruv Patel, Jeremy Vines, Xixi Zhang, David Chasteen-Boyd, Hak-Joon Sung, Yi-Ping Li, Amjad Javed, Shawn Gilbert, Kyounga Cheon & Ho-Wook Jun. Angiogenic and osteogenic synergy human mesenchymal stem cells and human umbilical vein endothelial cells cocultured on nanomatrix. Scientific Reports. 2018; 8, 15749
  • Chan-Yang Moon, Ok Hyung Nam, Misun Kim, Hyo-Seol Lee, Sagar N. Kaushik, David A. Cruz Walma, Ho-Wook Jun, Kyounga Cheon, Sung Chul Choi. Effects of NO releasing biomimetic nanomatrix gel on pulp dentin regeneration. PLOS ONE. 2018; 13 (10) e0205534.
  • Alexander GC, Vines JB, Hwang P et al. Novel Multifunctional Nanomatrix Reduces Inflammation in Dynamic Conditions in Vitro and Dilates Arteries ex Vivo. ACS Appl Mater Interfaces 2016;8:5178-87.
  • Andukuri A, Min I, Hwang P et al. Evaluation of the effect of expansion and shear stress on a self-assembled endothelium mimicking nanomatrix coating for drug eluting stents in vitro and in vivo. Biofabrication 2014;6:035019.
  • Kiwon Ban, Hun-Jun Park, Sangsung Kim, Adinarayana Andukuri, Kyu-Won Cho,JungWook Hwang, Ho Jin Cha, Sang Yoon Kim, Woan-Sang Kim, Ho-Wook Jun, and Young-Sup Yoon*. Cell Therapy with Embryonic Stem Cell-Derived Cardiomyocytes Encapsulated in Injectable Nanomatrix Gel Enhances Cell Engraftment and Promotes Cardiac Repair. ACS NANO. 2014; 8(10), 10815
  • Andukuri A, Sohn YD, Anakwenze CP et al. Enhanced human endothelial progenitor cell adhesion and differentiation by a bioinspired multifunctional nanomatrix. Tissue Eng Part C Methods 2013;19:375-85.
  • Andukuri A, Kushwaha M, Tambralli A et al. A hybrid biomimetic nanomatrix composed of electrospun polycaprolactone and bioactive peptide amphiphiles for cardiovascular implants. Acta Biomater 2011;7:225-33.
  • Andukuri A, Minor WP, Kushwaha M, Anderson JM, Jun HW. Effect of endothelium mimicking self-assembled nanomatrices on cell adhesion and spreading of human endothelial cells and smooth muscle cells. Nanomedicine 2010;6:289-97.
  • Kushwaha M, Anderson JM, Bosworth CA et al. A nitric oxide releasing, self assembled peptide amphiphile matrix that mimics native endothelium for coating implantable cardiovascular devices. Biomaterials 2010;31:1502-8.