Bionanomatrix

In many medical settings, devices are commonly used to help doctors treat patients. For example, stents are often used to open blocked arteries and repair torn vessels. Unfortunately, these devices fail often resulting in additional surgeries and often replacements of the original device. Endomimetics has developed a Bionanomatrix that can be used to coat these devices and mimic human tissue which minimizes the need for additional surgeries, improves the longevity of the device, reduces complications associated with having foreign items implanted in your body.

Bionanomatrix stent application

Endomimetics’ Bionanomatrix Provides The Following Key Attributes:

A reservoir for sustained release of nitric oxide promotes normal healthy vasodilation and inhibits inflammation.
An endothelial cell adhesive molecule, which promotes retention of endothelial cells.
Self-assembling amino acid chains that are free of solvents typically used in device coatings, which may cause inflammation or be toxic.

Advantages Of The Endomimetics Bionanomatrix Coating:

Inhibits blood clot formation
Inhibits re-narrowing within a stent or implant
Encourages healing of the normal arterial lining
Lacks residual polymer or solvent
Comprised of completely natural, peptide-based nanofibers

Literature

Below is a list of the technical literature on the various applications for the BioNanomatrix (click on the reference to download the PDF)

Maheshika Somarathna*, Patrick TJ. Hwang*, Reid C. Millican, Grant C. Alexander, Tatyana Isayeva-Waldrop, Jennifer A. Sherwood, Brigitta C. Brott, Isabella Falzon, Hannah Northrup, Yan-Ting Shiu, Chris J. Stubben, John Totenhagen, Ho-wook Jun, and Timmy Lee. Nitric oxide releasing nanomatrix gel treatment inhibits venous intimal hyperplasia and improves vascular remodeling in a rodent arteriovenous fistula. Biomaterials. 2022; 280, 121254.
Guang Ren, Patrick TJ. Hwang, Reid Millican, Juhee Shin, Brigitta C. Brott, Thomas Groen, Craig M. Powell, Sushant Bhatnager, Martin E. Young, Ho-Wook Jun, and Jeong-A Kim. Subcutaneous administration of a nitric oxide-releasing nanomatrix gel ameliorates obesity and insulin resistance in high-fat-diet-induced obese mice. ACS Applied Materials and Interfaces. 2022; 14(17), 19104-19115.
Patrick TJ. Hwang*, Jennifer A. Sherwood, Reid C. Milican, Pratheek S. Bobba, Tyler O. Lynd, Joseph N. Garner, Brigitta C. Brott, Dongming Hou, and Ho-Wook Jun. Endothelium-Mimicking Nanomatrix Coating to Enhance Endothelialization after Left Atrial Appendage Closure Device Implantation. ACS Applied Biomaterials. 2021; 4(6), 2917-4924
Grant C. Alexander, Patrick TJ. Hwang, Jun Chen, Jeong-a Kim, Brigitta C. Brott, Young Sup Yoon, Ho-Wook Jun. Nanomatrix coated stent enhances endothelialization but reduces platelet, smooth muscle cell, and monocyte adhesion under physiologic conditions. ACS Biomaterials Science & Engineering. 2018; 4(1), 107-115.
Jun Chen, Lily Deng, Catherine Porter, Grant Alexander, Dhruv Patel, Jeremy Vines, Xixi Zhang, David Chasteen-Boyd, Hak-Joon Sung, Yi-Ping Li, Amjad Javed, Shawn Gilbert, Kyounga Cheon & Ho-Wook Jun. Angiogenic and osteogenic synergy human mesenchymal stem cells and human umbilical vein endothelial cells cocultured on nanomatrix. Scientific Reports. 2018; 8, 15749
Chan-Yang Moon, Ok Hyung Nam, Misun Kim, Hyo-Seol Lee, Sagar N. Kaushik, David A. Cruz Walma, Ho-Wook Jun, Kyounga Cheon, Sung Chul Choi. Effects of NO releasing biomimetic nanomatrix gel on pulp dentin regeneration. PLOS ONE. 2018; 13 (10) e0205534.
Alexander GC, Vines JB, Hwang P et al. Novel Multifunctional Nanomatrix Reduces Inflammation in Dynamic Conditions in Vitro and Dilates Arteries ex Vivo. ACS Appl Mater Interfaces 2016;8:5178-87.
Andukuri A, Min I, Hwang P et al. Evaluation of the effect of expansion and shear stress on a self-assembled endothelium mimicking nanomatrix coating for drug eluting stents in vitro and in vivo. Biofabrication 2014;6:035019.
Kiwon Ban, Hun-Jun Park, Sangsung Kim, Adinarayana Andukuri, Kyu-Won Cho,JungWook Hwang, Ho Jin Cha, Sang Yoon Kim, Woan-Sang Kim, Ho-Wook Jun, and Young-Sup Yoon*. Cell Therapy with Embryonic Stem Cell-Derived Cardiomyocytes Encapsulated in Injectable Nanomatrix Gel Enhances Cell Engraftment and Promotes Cardiac Repair. ACS NANO. 2014; 8(10), 10815
Andukuri A, Sohn YD, Anakwenze CP et al. Enhanced human endothelial progenitor cell adhesion and differentiation by a bioinspired multifunctional nanomatrix. Tissue Eng Part C Methods 2013;19:375-85.
Andukuri A, Kushwaha M, Tambralli A et al. A hybrid biomimetic nanomatrix composed of electrospun polycaprolactone and bioactive peptide amphiphiles for cardiovascular implants. Acta Biomater 2011;7:225-33.
Andukuri A, Minor WP, Kushwaha M, Anderson JM, Jun HW. Effect of endothelium mimicking self-assembled nanomatrices on cell adhesion and spreading of human endothelial cells and smooth muscle cells. Nanomedicine 2010;6:289-97.
Kushwaha M, Anderson JM, Bosworth CA et al. A nitric oxide releasing, self assembled peptide amphiphile matrix that mimics native endothelium for coating implantable cardiovascular devices. Biomaterials 2010;31:1502-8.